“Good On” time refers to the sum of “On” time without dyskinesia plus “On” time with non-troublesome dyskinesia. Drs Richard B. Dewey Jr and Rajesh Pahwa detail the importance of achieving more “Good On” time and highlight its value as a clinical indicator for successful motor symptom control.
Since levodopa first appeared in clinical practice, continued efforts have been made to advance levodopa therapy by developing formulations that provide long-lasting benefits. Drs Fiona Gupta and Stuart H. Isaacson explore its history, evolution and discuss its clinical use.